相关实验视频
Updated: May 15, 2025

11:12
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
22.1K
皮马万塞林对帕金森病处方实践的影响
Thanh Phuong Pham Nguyen1,2,3, Vy Le4, Daniel Weintraub5,6
1Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Clinical parkinsonism & related disorders
|April 10, 2025
概括
皮马万塞林在帕金森病精神病 (PDP) 中的使用在2016年批准后增加,减少了有害抗精神病药物的使用. 然而,喜欢的药物,如氨酸仍然是最常见的,强调了对比疗效研究的需要.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 帕金森病精神病 (PDP) 是帕金森病 (PD) 的一个常见的,使人虚弱的并发症.
- 用于PDP的传统抗精神病药物存在由于多巴胺受体对抗性 (DRA) 导致运动症状恶化的风险.
- 皮马万塞林是一种非典型的抗精神病药物 (AAP),没有显著的DRA,于2016年获得批准,提供了一个新的治疗选择.
研究的目的:
- 评估pimavanserin的引入对美国商业保险人口中PDP抗精神病药物的处方模式的影响.
- 为了比较皮马万塞林的发行趋势,在PDP患者中首选的AAP (克洛扎宾,奎平) 和非首选的AAP.
- 分析这些趋势在一般人群和医疗保险优势65+亚群中.
主要方法:
- 从2016年到2022年对处方发行数据的回顾性分析.
- 纳入标准:被诊断患有PD的成年人,至少有一份AAP处方.
- 将AAP分为pimavanserin,首选 (克洛扎宾,奎蒂亚宾) 和非首选组的分类;每1000人每季度发放率的比较.
主要成果:
- 皮马万塞林的发行率大幅增加,到2018年底超过非偏好的AAP.
- 尽管pimavanserin的可用性,首选的AAP,特别是氨酸,在整个研究期间仍然是最常用的类别.
- 在Medicare Advantage 65+亚群中观察到类似的发行趋势.
结论:
- 皮马万塞林的引入导致了对PDP的潜在更有害的AAP的利用率下降.
- 奎蒂亚平和其他首选的AAP继续主导PDP治疗,表明需要进一步评估.
- 对比性研究对于确定PDP不同治疗选择的最佳风险-益处概况至关重要.
相关概念视频
Parkinson's Disease: Treatment
161
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
161
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
101
Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
101
Parkinson's Disease: Overview
342
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
342
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
52
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
A study on guinea pigs examined the...
52
Pharmacovigilance
753
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
753
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
120
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
120

