HPV和共感染:对精液炎症,氧化应激和精子质量的影响
Carolina Olivera1,2, Daniela A Paira1,2, Andres Olmedo3
1Federation of Clinical Immunology Societies (FOCIS) Center of Excellence, Centro de Inmunología Clínica de Córdoba (CICC), Córdoba, Argentina.
Frontiers in cellular and infection microbiology
|April 10, 2025
概括
人类乳头瘤病毒 (HPV) 单独不会影响男性生育能力. 然而,当HPV与Chlamydia trachomatis (CT) 共感染时,它会显著降低精子质量并增加精液炎症.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 生殖医学 生殖医学
背景情况:
- 人类乳头瘤病毒 (HPV) 是一种常见的性传播疾病,与男性泌尿器官炎症和潜在的生育问题有关.
- 关于HPV对男性生育能力的影响和共感染的影响的证据有限且不确.
研究的目的:
- 调查HPV男性泌尿器感染的患病率及其对精液炎症生物标志物,氧化应激和精子质量的影响.
- 探索HPV与其他尿病原体共感染对男性生殖健康的影响.
主要方法:
- 分析了参加泌尿外科诊所的205名男性的HPV患病率和并发症.
- 评估了精子白细胞子集,炎症性细胞因子 (IL-6),精液参数,亡,亡和反应性氧物种 (ROS) 生产.
主要成果:
- 在19%的男性中发现了HPV感染,其中74.4%被其他泌尿病原体感染,最常见的是Chlamydia trachomatis (CT, 52%).
- 单一的HPV感染对精子质量或精液炎症没有显著影响.
- HPV和CT共感染显著损害了精子度和运动性,并增加了精液中的IL-6水平.
结论:
- 单次HPV感染与精液炎症或精子质量的显著变化无关.
- 同时感染CT显著导致精液炎症和精子质量降低.
- 同时的HPV和CT感染代表着一个独特的临床实体,影响男性生育能力.
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