传染性脑炎病毒亚型:特定和非特定的单种和混合感染
Alexandra E Polienko1, Oxana A Belova1, Alexander G Litov1,2
1Laboratory of Biology of Arboviruses, Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences (Institute of Poliomyelitis), Moscow, Russia.
Frontiers in cellular and infection microbiology
|April 10, 2025
概括
传播性脑炎病毒 (TBEV) 在各种物种中有效繁殖. 然而,在适应过程中,病毒感染力会发生变化,这表明适应取决于病毒菌株和物种,而不仅仅是繁殖水平.
科学领域:
- 病毒学 病毒学
- 载体传播疾病 载体传播疾病
- 昆虫学 昆虫学是一门学科.
背景情况:
- 感染性脑炎病毒 (TBEV) 有三个主要亚型:欧洲 (Eu),西伯利亚 (Sib) 和远东 (FE).
- TBEV是由Ixodes ricinus和Ixodes persulcatus传播的,而Dermacentor reticulatus也充当了一种合格的载体.
- 建议在TBEV变种和物种之间进行特定的适应,包括当地种群.
研究的目的:
- 研究不同物种和种群的TBEV繁殖和传染性.
- 确定影响TBEV适应新载体的因素.
- 分析物种内TBEV维持的种群间差异.
主要方法:
- 每种Ixodes ricinus,Ixodes persulcatus和Dermacentor reticulatus的两个种群的皮肤感染了三种TBEV菌株.
- 使用实时PCR和斑块分析量化TBEV RNA副本和传染性病毒颗粒.
- 在细胞培养 (PEK) 中估计单种和混合感染期间的病毒动态.
主要成果:
- 所有测试的物种 (I. ricinus,I. persulcatus,D. reticulatus) 都有效地支持了TBEV的繁殖.
- 在I. persulcatus (单一和混合感染) 和I. ricinus (混合感染) 中观察到TBEV繁殖的种群间差异.
- 虫持续存在期间,对哺乳动物细胞的TBEV感染性发生了变化,TBEV-Eu在适应非特异性虫物种时增加了感染性.
结论:
- TBEV的繁殖水平不是决定适应新物种的主要因素.
- 在TBEV感染性的变化取决于特定的病毒菌株和涉及的虫物种.
- 当地种群可以在支持TBEV繁殖方面表现出变异,突出显示了复杂的宿主病毒相互作用.
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