时间限制的饮食和自身主导性多囊性病:一个试点,随机的临床试验
Cortney Steele1, Anna Ostrow1, Wei Wang1
1Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Clinical kidney journal
|April 10, 2025
概括
时间限制的饮食 (TRE) 在12个月的时间内没有显著减缓自身主导性多囊性病 (ADPKD) 患者的囊生长. 体重和脂肪的减少,而不是吃的时间,可能是控制体积的关键因素.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢障碍 代谢障碍 代谢障碍
- 饮食干预 饮食干预
背景情况:
- 自体主导多囊性病 (ADPKD) 是一种常见的遗传性渐进性病.
- 临床前研究表明,时间限制饮食 (TRE) 可能会抑制囊的生长.
研究的目的:
- 评估TRE在减缓ADPKD患者囊生长中的有效性.
- 将TRE与健康饮食 (HE) 控制组进行12个月的比较.
主要方法:
- 一个为期12个月的随机对照试验比较了TRE (8小时的饮食窗口) 与HE (没有TRE).
- 参与者接受了MRI,以测量高度调整的脏总体积 (htTKV) 和脂肪度.
- 坚持饮食窗口是主要结果.
主要成果:
- TRE的遵守率为60%,低于75%的目标.
- 两组都经历了适度的体重减轻;没有观察到htTKV变化的显著差异.
- 体重和内脏脂肪变化与htTKV变化呈正相关性.
结论:
- 与HE相比,TRE没有显著减少体积增加.
- 在ADPKD中,减肥和减肥似乎比饮食时间更为关键,以促进脏生长.
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