肠道殖民性Streptococcus oralis对小鼠膀健康的致病作用
Natsuno Nakamura1,2, Kota Iioka2,3, Hirobumi Morisaki2
1Department of Special Needs Dentistry, Division of Dentistry for Persons with Disabilities, School of Dentistry, Showa University, 2-1-1 Kitasenzoku, Ohta-ku, Tokyo 145-8515, Japan.
Current research in microbial sciences
|April 10, 2025
概括
口腔细菌Streptococcus oralis,当殖民肠道时,会导致小鼠的膀炎症和纤维化. 这表明S. oralis可能会影响远处的器官,可能导致非细菌性囊炎.
科学领域:
- 微生物学 微生物学
- 病理学 病理学 病理学
- 免疫学 免疫学 免疫学
背景情况:
- 口腔 estreptococcus oralis 是一种常见的口腔细菌和机会性病原体.
- 它在引起口腔以外的疾病中的作用尚未完全理解.
研究的目的:
- 在体内调查Streptococcus oralis的致病性.
- 为了确定S. oralis对肠道殖民是否会影响宿主组织.
主要方法:
- 没有细菌的小鼠被口服注射S. oralis,以建立肠道殖民.
- 对殖民小鼠的后代进行了分析,以检测S. oralis的存在和宿主组织变化.
- 膀组织被通过基因病理学和RNA测序检查.
主要成果:
- 在肠道中检测到S. oralis,导致软便,但没有显著的肠道炎症.
- 殖民小鼠表现出尿动频率增加和膀病理 (缩,,纤维化,脱皮).
- 膀基因表达显示慢性炎症和细胞外矩阵组织增加,抗氧化应激反应减少.
结论:
- 肠道被Streptococcus oralis殖民导致老鼠慢性膀炎症和纤维化.
- S. oralis可以影响远部组织,这表明在非细菌性囊炎等疾病中具有病原性作用.
- 这项研究揭示了口服开始和泌尿系统健康之间的潜在联系.
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