麻醉症早在儿童时期就与亚临床心血管疾病有关:大数据分析
Christopher N Kaufmann1, Munaza Riaz2, Haesuk Park2
1Department of Health Outcomes and Informatics, College of Medicine University of Florida Gainesville FL.
Journal of the American Heart Association
|April 10, 2025
概括
麻醉症显著增加了心血管疾病 (CVD) 和相关疾病的风险,即使在儿童中也是如此. 在麻醉症患者中早期检测这些亚临床心血管疾病结果对于预防未来心血管事件至关重要.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 儿科 儿科 儿科
背景情况:
- 麻醉症与心血管疾病 (CVD) 风险增加有关.
- 有限的研究存在于麻醉症与亚临床心血管疾病的联系,特别是在儿童群体.
- 亚临床心血管疾病标志物包括高血压,高脂血症,糖尿病和非酒精性脂肪肝疾病/非酒精性脂肪肝炎 (NAFLD/NASH).
研究的目的:
- 调查麻醉症和亚临床心血管疾病 (CVD) 结局之间的关联.
- 在麻醉患者中评估高血压,高脂血症,糖尿病和NAFLD/NASH的风险.
- 为了评估心血管疾病复合和主要不良心血管事件 (MACE) 在麻醉症患者.
主要方法:
- 使用MarketScan商业和医疗保险补充数据库 (2005-2021) 的回顾性队列研究.
- 包括22293名被诊断为麻醉症 (NT1和NT2) 的患者和63,709名倾向性得分匹配的对照.
- 通过1年内≥2个门诊病患索赔确定了麻醉症,其中有1个非诊断索赔;结果评估后指数日期.
主要成果:
- 麻醉症患者的高血压 (HR 1.40),高脂血症 (HR 1.41),糖尿病 (HR 1.50) 和NAFLD/NASH (HR 1.48) 的风险显著增加.
- 对心血管疾病复合物 (HR 1.61) 和MACE (HR 1.69) 也观察到增加的风险.
- 经过对麻醉症药物进行调整后,研究结果仍然显著,并且在所有年龄组中一致,包括25岁以下的年龄组.
结论:
- 麻醉症与亚临床心血管疾病的风险明显增加有关,甚至在儿童时期也表现出来.
- 在麻醉症患者中早期识别亚临床心血管疾病标志物至关重要.
- 主动管理可以减轻麻醉症患者心血管事件的长期负担.
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