在CPAP治疗后残留的周期性四肢运动指数与低氧症有关
Lourdes M DelRosso1, Harshill Modi2, Viraj Jain3
1University of California San Francisco, Fresno, California.
概括
在睡眠期间持续的周期性四肢运动 (PLMS) 在接受CPAP治疗的阻塞性睡眠呼吸暂停 (OSA) 患者中很常见. 男性性别,较高的BMI和显著的低氧化预测剩余的PLMS.
科学领域:
- 睡眠医学 睡眠医学
- 呼吸系统医学 呼吸系统医学
- 神经学 神经学
背景情况:
- 睡眠期间的肢体周期性运动 (PLMS) 通常与阻塞性睡眠呼吸暂停 (OSA) 一起发生.
- 在OSA患者中,持续正气道压力 (CPAP) 对PLMS的影响尚未完全理解.
- 了解在CPAP期间影响PLMS持续性的因素对于有效治疗至关重要.
研究的目的:
- 调查与定期四肢运动指数 (PLMI) 持久性相关的因素,在接受CPAP治疗OSA的成年患者中.
- 为了确定剩余PLMS的预测因子,尽管有效的CPAP治疗.
主要方法:
- 一项回顾性横截面研究包括107名OSA成年患者接受CPAP治疗.
- 患者根据CPAP治疗期间的PLMI变化进行分类:正常,持续升高,恶化或消失.
- 后勤回归分析用于评估预测因素,包括睡眠架构,氧气脱,年龄和BMI.
主要成果:
- 几乎一半的患者 (47.5%) 尽管使用CPAP,但仍有持续升高的PLMI.
- 男性性别 (OR=5.38),更高的BMI (OR=1.09),以及在诊断性多睡眠记录 (OR=1.034) 中增加氧和时间≤88%是残留PLMI的显著预测因素.
- 睡眠架构参数与剩余PLMI没有独立相关.
结论:
- 剩余的PLMS是用CPAP治疗的OSA患者的常见发现.
- 男性性别,较高的BMI和诊断睡眠研究期间显著的氧气不足与持续的PLMS独立相关.
- 这些发现突出了特定的患者特征,可能需要针对OSA的PLMS制定有针对性的管理策略.
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