"精准医学"和对二进制大脑性别差异的失败的搜索,以解决性别行为健康差异
1Chicago Medical School, Stanson Toshok Center for Brain Function and Repair, Rosalind Franklin University of Medicine & Science, North Chicago, Illinois, USA.
概括
几十年来对性别差异进行的大脑成像研究过于简化了性别,未能取得承诺的临床进展. 未来的研究必须检查特定的行为和细微的性别/性别因素,以更好地了解大脑健康.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 社会学 社会学 社会学
背景情况:
- 自20世纪80年代以来,人类大脑成像研究已广泛研究性别差异,旨在准确医学.
- 这项研究主要采用二元男性/女性 (M/F) 方法,假设神经成像中的性别差异将推进神经精神疾病治疗.
- 尽管进行了40年的研究,但这种二进制方法的承诺在很大程度上仍未实现.
研究的目的:
- 为了审查现代神经成像中关于男性和女性大脑差异的历史声明.
- 分析推动性别差异研究的财务激励因素.
- 检查二元性别方法在理解与性别相关的行为和健康差异方面的局限性.
主要方法:
- 关于性别差异的历史神经成像研究的审查.
- 对过于简单的二进制性别分类的影响分析.
- 检查最近试图在脑成像中将多维性别测量与性别相结合的尝试.
主要成果:
- 在脑成像研究中对性别的二元方法已经产生了有限的实质性发现.
- 对性别的过度简化和对性别的无知作为一个复杂的变量阻碍了对行为和心理健康的理解.
- 通过包括性别措施来"打破二元"的最初努力也产生了有限的实质性结果.
结论:
- 在脑成像研究中对性行为的过度二元化未能实现其治疗承诺.
- 需要一种更细微的方法,超越简单的M / F分类.
- 未来的研究应该专注于特定的行为和性别和性别的多方面的组成部分,以解决大脑健康方面的差异.
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