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Updated: May 15, 2025

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
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信号轴PIN1-p38-CtIP保护停滞的复制分叉免受有害的降解

Francesca Vivalda1, Marco Gatti1, Letizia Manfredi1

  • 1Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland.

Nucleic acids research
|April 10, 2025
PubMed
概括

PIN1-p38-CtIP途径稳定了停滞的复制分叉,这对基因组稳定性至关重要. 这一途径对于保护分叉是必不可少的,但对于同源重组是不可或缺的,提供了新的治疗点.

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