儿科系统性红斑狼的早期动脉样硬化:系统性审查和元分析
Pratap Kumar Patra1, Aaqib Zaffar Banday2, Adil Asghar3
1Department of Pediatrics, All India Institute of Medical Sciences (AIIMS) Patna, Bihar, India.
International journal of rheumatic diseases
|April 10, 2025
概括
儿科系统性红斑狼 (pSLE) 与动脉内膜介质厚度和脉冲波速度的增加有关,这表明潜在的心血管风险. 需要进一步的研究来证实这些发现,并评估PSLE儿童的长期心血管结果.
科学领域:
- 儿科风湿病学中的心血管健康.
- 在自身免疫性疾病中的血管并发症.
背景情况:
- 患有全身性红斑狼 (SLE) 的成年人面临更高的心血管风险,并表现出亚临床动脉样硬化的迹象.
- 现有的元分析专注于成人SLE,在了解儿科SLE (pSLE) 的心血管影响方面存在差距.
研究的目的:
- 系统地审查和对儿科SLE亚临床动脉样硬化研究进行元分析.
- 评估PSLE对心血管健康参数的影响.
主要方法:
- 在Embase,科学网络和PubMed (1965-2024) 的系统文献搜索.
- 包括比较PSLE患者与健康对照者的研究.
- 使用Review Manager和R软件进行数据提取,质量评估和元分析.
主要成果:
- 分析了9项涉及1021名参与者的研究 (528名PSLE,493名对照).
- 在pSLE患者中显著更高的动脉内心介质厚度 (CIMT) 和脉冲波速度 (PWV).
- 疾病持续时间与增加的CIMT和PWV相关.
结论:
- 低质量的证据表明,PSLE对血管微解剖学和生理学产生不利影响.
- 长度研究对于准确确定儿科SLE患者心血管风险至关重要.
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