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Updated: May 15, 2025

Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics Under Physiological Conditions
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Published on: June 23, 2022

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局部离子条件调节聚合倾向并影响α-Synuclein的结构多态性.

Maria Zacharopoulou1, Neeleema Seetaloo2, James Ross3

  • 1Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.

Journal of the American Chemical Society
|April 10, 2025
PubMed
概括

像 (Ca2+) 和 (Na+) 这样的生理相关离子加速α-synuclein (aSyn) 聚合,这是帕金森病 (PD) 的关键过程. 离子度影响aSyn结构和纤维细胞的形成,为PD机制提供了洞察力.

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