整合肠-大脑轴:探索自闭症谱系障碍中的神经胃肠相互作用和治疗潜力
Manjeet Kumar1, Sidharth Mehan1, Tarun Sharma1
1Division of Neuroscience, Department of Pharmacology, ISF College of Pharmacy, Moga, Punjab, India (Affiliated to IK Gujral Punjab Technical University, Jalandhar, Punjab, 144603, India.
Endocrine, metabolic & immune disorders drug targets
|April 10, 2025
概括
肠-大脑轴 (GBA) 和肠道微生物群与自闭症谱系障碍 (ASD) 有着重要的联系. 改变的肠道环境可能会影响ASD行为,并为基于微生物组的治疗提供点.
科学领域:
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 肠-大脑轴 (GBA) 是一个双向通信网络,连接肠道,大脑和微生物群.
- 自闭症谱系障碍 (ASD) 是一种发育状况,具有神经系统不规则性和频繁的胃肠道 (GI) 问题.
- 在ASD患者中观察到肠道微生物组合的改变,这表明肠道健康和ASD之间存在联系.
研究的目的:
- 批判性地审查GBA在ASD中的影响.
- 探索肠道微生物群在ASD病理生理学的作用.
- 讨论新兴的基于微生物组的ASD治疗方法.
主要方法:
- 关于肠-大脑轴和ASD的研究的综合文献综述.
- 分析介导GBA通信的生理途径 (ENS,迷走神经,免疫,代谢).
- 检查ASD神经发育中的遗传和环境因素.
主要成果:
- 在ASD中胃肠道障碍的患病率增加与行为严重程度相关.
- 在ASD中肠道微生物群的改变会影响代谢,免疫,氧化应激,线粒体和神经递质功能.
- 新出现的证据支持基于微生物的干预措施,如益生菌,益生菌和ASD的FMT.
结论:
- 在ASD中,GBA起着至关重要的作用,肠道微生物群影响神经健康.
- 综合遗传学,神经科学,心理学和胃肠病学的多学科方法对于理解ASD至关重要.
- 为了开发有效的,个性化的ASD治疗方法,需要进一步的研究和道德监督.
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