Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

165
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
165

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Quantitative contribution of dissolution-driven precipitation to Pb(II) removal by biochars during adsorption process.

Scientific reports·2026
Same author

Multi-omics profiling of oxeiptosis-associated biomarkers in cancer.

Clinica chimica acta; international journal of clinical chemistry·2026
Same author

Computational evaluation of leflunomide and ticagrelor combination targeting the A2A receptor for the management of rheumatoid arthritis.

Pakistan journal of pharmaceutical sciences·2026
Same author

Formulation and in-vitro characterization of okra mucilage-based controlled release hydrogels.

Pakistan journal of pharmaceutical sciences·2026
Same author

Intravenous proton pump inhibitor uses for stress ulcer prophylaxis in the critically ill: a single-center study in Pakistan.

Journal of infection in developing countries·2026
Same author

Passive subambient cooling and atmospheric water nexus.

Nature communications·2026

相关实验视频

Updated: May 5, 2026

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

11.0K

布罗莫克里的β-Cyclodextrin功能化纳米载体:开发,评估和组织病理学研究.

Muhammad Ahsan Waqar1, Iqra Noor Khan2, Shabab Zahra3

  • 1Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Lahore University of Biological and Applied Sciences, Lahore, Pakistan.

Journal of microencapsulation
|April 10, 2025
PubMed
概括

这项研究开发了一种用于帕金森病治疗的新型烯胺纳米乳液,通过鼻内路线增强药物向大脑的输送. 该配方显示改善了生物可用性和稳定性,为口服烯胺提供了一个有前途的替代品.

关键词:
布罗莫克里普提因 (bromocriptine) 是一种蛋白质.帕金森病是帕金森氏症的一种疾病.纳米乳液是一种纳米乳液.泽塔潜力是一个潜力.这是一种β-cyclodextrin.

更多相关视频

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

14.8K
Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.0K

相关实验视频

Last Updated: May 5, 2026

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
07:53

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier

Published on: April 26, 2016

11.0K
Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
09:56

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles

Published on: August 2, 2016

14.8K
Formulation and Characterization of Bioactive Agent Containing Nanodisks
07:58

Formulation and Characterization of Bioactive Agent Containing Nanodisks

Published on: March 17, 2023

1.0K

科学领域:

  • 制药科学 制药科学
  • 纳米技术纳米技术
  • 神经科学是一个神经科学.

背景情况:

  • 甲 (BCM) 由于广泛的第一通代谢和有限的吸收,具有较差的口服生物利用性.
  • 在帕金森病 (PD) 治疗中,有效地将多巴胺激素激动剂输送到大脑至关重要.
  • 目前的传递方法在克服系统障碍和实现有针对性的大脑传递方面面临着挑战.

研究的目的:

  • 开发一种β-cyclodextrin功能化的烯酸纳米乳液,以提高溶解度,稳定性和生物可用性.
  • 为了促进直接的鼻内脑输送布罗莫克里普丁,绕过系统代谢.
  • 为了提高帕金森病的治疗疗效,减少全身副作用.

主要方法:

  • 使用高剪切均质化制备油在水纳米乳液.
  • 通过SEM,Malvern Zetasizer (球体大小,泽塔潜力),FTIR,XRD和DSC进行表征.
  • 药物含量的评估,体外药物释放和体外透.
  • 稳定性研究 (离心,冷解),对接研究,以及组织病理学评估.

主要成果:

  • 均的纳米尺寸球状粒子 (117.2 nm) 具有较低的PDI (0.810) 和良好的体稳定性 (泽塔电位-10.5 mV).
  • 在优化的配方 (F4) 中,高封装效率 (95.36%) 和药物负载 (9.5% w/w).
  • 显著的体外药物释放 (85.65%) 和体外透 (78.44%),具有证明的稳定性和出色的生物相容性.

结论:

  • 开发的β-cyclodextrin-functionalized bromocriptine纳米乳液有效地提高了药物的输送和稳定性.
  • 通过这种纳米乳液进行鼻内输送为帕金森病治疗提供了一个有前途的策略.
  • 该配方显示出改善治疗结果的潜力,并尽量减少系统性不良影响.