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作为一种药物输送系统,具有用于皮肤伤口包裹的潜在用途的珠子纤维形态的解决方案吹螺丝

Javier Mauricio Anaya-Mancipe¹, Aline Luiza Machado Carlos¹, João Victor Dias de Assumpção Bastos¹

¹Program of Metallurgical and Materials Engineering-PEMM/COPPE, Universidade Federal do Rio de Janeiro (UFRJ), 21941-598 Rio de Janeiro, RJ, Brazil.

ACS applied materials & interfaces

|April 10, 2025

概括

使用溶液吹 (SBS) 的组织工程创造了PCL/PEG纳米纤维地毯. 这些子有效地提供布洛芬来缓解疼痛,并通过促进细胞迁移来加速伤口愈合的潜力.

科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
药物输送系统药物输送系统

背景情况:

组织工程策略对于在受伤后恢复皮肤完整性至关重要.
解决方案吹 (SBS) 提供连续的纳米纤维生产,具有高孔隙性和局部药物输送能力.

研究的目的:

开发和封装布洛芬在聚烯 (PCL) /聚乙烯糖醇 (PEG) 纳米纤维地毯内.
为创建一个快速起作用的止痛药物输送系统,用于伤口愈合应用.

主要方法:

使用溶液吹 (SBS) 制造PCL/PEG珠型纳米纤维结构.
优化SBS参数 (PEG度,气压,注射速率) 和通过SEM分析纤维形态.
包装布洛芬在优化的PCL/PEG子中,以不同度 (5%,15%,30%).

主要成果:

在特定的条件下 (137.90 kPa,7.2 mL/h) 制造了优化的PCL/PEG (1:1比) 地毯.
在SBS织的地毯上,出现了显著的胀 (约. 400%) 并在5小时内促进了布洛芬的逐渐释放.
在伤口愈合试验中,布洛芬载促进了中性粒细胞 (NF) 迁移.

结论:

由SBS生产的PCL/PEG纳米纤维地毯是ibuprofen的有效药物输送系统.
开发的地毯显示出由于增强的细胞迁移而加速伤口愈合的潜力.
这种方法为局部疼痛管理和组织再生提供了一个有希望的策略.

关键词:

生物活跃的伤口包裹.药物输送是药物输送的过程.不同质的结构不同质的结构.伊布罗芬是什么意思伊布罗芬是什么意思解决方案吹旋转旋转的方法

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