哺乳动物的出生与冬眠的唤醒:甲状腺激素,代谢过渡的常见调节者?

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Melanie Heidkamp¹, Annika Herwig², Dominique Singer³

¹Division of Neonatology and Pediatric Critical Care Medicine, Center for Obestrics and Pediatrics, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology

|April 10, 2025

概括

甲状腺激素 (THs) 对于哺乳动物出生和从冬眠中唤醒期间的代谢过渡至关重要. 虽然新生儿的TH水平增加,但冬眠者表现出不同的反应,这表明组织转化是激发的关键.

科学领域:

内分泌学在内分泌学.
比较生理学比较生理学
哺乳动物生理学哺乳动物生理学

背景情况:

哺乳动物的出生和从冬眠中唤醒是关键的过渡状态,涉及代谢率的增加和发热.
甲状腺激素 (THs) 是已建立的新陈代谢和发热的调节者.

研究的目的:

为了比较甲状腺激素在哺乳动物出生期间的作用和动力学,与冬眠的兴奋相比.
在这些过渡状态中,检查甲状腺释放激素 (TRH),甲状腺刺激激素 (TSH),甲状腺素 (T4),三甲状腺素 (T3) 和反向三甲状腺素 (rT3) 的血清水平.

主要方法:

对冬眠哺乳动物在唤醒时和新生儿出生时血清激素水平的综合文献综述.
对不同物种和采样条件的TRH,TSH,T4,T3和rt3动态的分析.

主要成果:

冬眠的唤醒显示了异质的结果:TRH下降,TSH不变,主要增加T4,T3和RT3.
哺乳动物的出生表明TRH,TSH,T4和T3的显著增加,特别是在人类新生儿中,具有变量RT3.
冬眠和方法的物种差异有助于唤醒结果异质性.

结论:

虽然THs至关重要,但不仅仅负责这两种状态中的代谢过渡.
在冬眠状态下,TH的作用很可能依赖于目标组织的转化率,表明准备激发.
新生哺乳动物经历了最初的甲状腺激活,导致过渡性甲状腺过高状态独立生活.

关键词:

激发性唤起性唤起性出生出生出生出生出生出生出生出生冬眠状态冬眠状态哺乳动物哺乳动物甲状腺是什么?甲状腺是什么?托尔波尔 (Torpor) 是一个令人惊的.

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