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Jennifer M Wang¹, Swaraj Bose², Susan Murray²

¹University of Michigan Michigan Medicine, Pulmonary and Critical Care, Ann Arbor, Michigan, United States; wangjenn@med.umich.edu.

Annals of the American Thoracic Society

|April 10, 2025

概括

在低剂量CT扫描中对间歇性肺病 (ILD) 的定量成像预测了大量查人群的死亡风险. 这些发现强调了定量ILD测量对有烟草使用史的人的预后价值.

科学领域:

肺部医学肺部医学
放射学放射学是指放射学
定量成像技术定量成像技术

背景情况:

胸部CT扫描中的偶然间歇性肺病 (ILD) 与不良结果有关.
对ILD的定性评估是常见的,但定量成像为风险分层提供了潜力.

研究的目的:

调查国家肺部查试验 (NLST) 中定量ILD测量和临床结果之间的关联.

主要方法:

定量ILD测量 (地板玻璃不透明度,网状不透明度,蜂) 来自使用CALIPER和DL-UIP算法的LDCT扫描.
考克斯比例危险回归分析了ILD措施与所有原因死亡率,肺癌发病率和肺癌死亡率之间的关联.

主要成果:

增加全因死亡风险与较高的磨砂玻璃不透明度,网状不透明度和蜂的百分比相关.
基于深度学习的常见间歇性肺炎 (DL-UIP) 的积极分类与所有死因死亡风险增加4.8倍相关.
网膜不透明与肺癌死亡率的增加有关,但没有定量ILD测量预测发生的肺癌.

结论:

对LDCT的定量ILD评估是预测高风险人群死亡率的宝贵工具.
这些成像生物标志物可以帮助对有烟草使用史的人进行风险分层.

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