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Updated: May 23, 2025

Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
06:03

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代谢重编程和渐进性肺纤维化需要PERK/ATF4通路

Jyotsana Pandey1, Jennifer L Larson-Casey1, Mallikarjun H Patil1

  • 1Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

JCI insight
|April 10, 2025
PubMed
概括

蛋白激酶RNA类ER激酶 (PERK) 在肺巨细胞中的激活驱动着石棉诱导的纤维化. 抑制PERK可以逆转已有的纤维化,这表明它是治疗这种渐进性肺病的潜在治疗标.

关键词:
脂肪酸氧化过程中的脂肪酸氧化.纤维化 纤维化 纤维化免疫学 免疫学 免疫学巨细胞是一个巨细胞.肺部病理学 肺部病理学

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