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Updated: May 15, 2025

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药物遗传学以优化系统性红斑狼的免疫抑制疗法:一个范围审查

Alim Khodimul Rahmat1,2, Irmasari2, Zahrotun Nafiah2

  • 1Doctor's Program in Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Pharmacogenomics
|April 10, 2025
PubMed
概括

遗传变异会影响免疫抑制剂在系统性红斑狼 (SLE) 中的作用. 了解这些遗传差异可以个性化治疗并改善SLE患者的治疗结果.

关键词:
系统性红血性狼 (Systemic lupus erythematosusus) 是一种全身性狼.遗传多形态的遗传多形态.免疫抑制剂 免疫抑制剂药物遗传学 药物遗传学精准医学是一门精准医学.

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A drug's nonlinear kinetics can be influenced by a diverse range of transporter proteins that serve as crucial players in drug distribution. These transporters, found within cells, can enhance or reduce local drug concentrations by facilitating the influx or efflux of drugs. For instance, the expression of xenobiotic transporters can be influenced by factors such as age and gender, potentially impacting the linearity of drug response.
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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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