来自中间前额叶皮层的自上而下的预测信号控制着听觉皮层的预测错误
Adam Hockley1, Laura H Bohórquez1, Manuel S Malmierca1
1Cognitive and Auditory Neuroscience Laboratory, Institute of Neuroscience of Castilla y León (INCYL), Salamanca, Spain; Salamanca Institute for Biomedical Research (IBSAL), Salamanca, Spain; Department of Cell Biology and Pathology, Faculty of Medicine, University of Salamanca, Salamanca, Spain.
Cell reports
|April 10, 2025
概括
中间前额叶皮层 (mPFC) 发送预测,帮助大脑检测出意想不到的声音. 在mPFC中阻止这些自上而下的信号可以减少主要听觉皮层 (A1) 中的听觉预测错误.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 审计处理 审计处理
背景情况:
- 大脑根据预测编码框架的过去经验预测环境刺激.
- 感官输入与内部模型进行比较,在发生不匹配时产生预测错误.
- 预测错误在主要听觉皮层 (A1) 和中间前额叶皮层 (mPFC) 连续观察到.
研究的目的:
- 研究中部前额叶皮质 (mPFC) 在产生预测错误中的作用.
- 测试mPFC的自上而下的预测是否有助于在A1.1中产生听觉预测错误.
主要方法:
- 利用光遗传学来抑制来自mPFC的自上而下的神经信号.
- 在听觉奇怪范式期间,在主要听觉皮层 (A1) 中记录了神经元活动.
- 对比了对罕见,可预测和随机听觉刺激的预测错误反应.
主要成果:
- 抑制mPFC的自上而下的信号显著减少了A1对罕见声音的响应预测错误.
- 抑制mPFC并没有改变对可预测或随机听觉刺激的A1反应.
- 这表明mPFC的自上而下的预测在处理不可预测的听觉事件方面发挥了特定的作用.
结论:
- 中间前额叶皮层 (mPFC) 提供自上而下的预测信号,这些信号对于产生听觉预测错误至关重要.
- 这些发现从经验上支持mPFC预测对增强初级听觉皮层 (A1) 对意想不到的刺激反应的贡献.
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