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Updated: May 15, 2025

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具有铁素作为分子链的PROTAC连接器的合理设计,以实现动态形态变化

Alessandra Salerno1, Lianne H E Wieske1, Claudia J Diehl1

  • 1Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee DD1 5JJ, U.K.

Journal of the American Chemical Society
|April 10, 2025
PubMed
概括

介绍FerroTACs,一种使用铁素结合剂的新型蛋白解向化马 (PROTAC) 策略. 这种创新设计提高了细胞透性和目标降解,为下一代PROTAC开发提供了多功能平台.

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