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相关概念视频

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences01:20

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS): Interferences

336
Inductively coupled plasma–mass spectrometry (ICP–MS) is a highly selective and sensitive technique for accurate elemental analysis. Though the analysis of ICP–MS mass spectra is comparatively straightforward, it is affected by spectroscopic and non-spectroscopic interferences. Spectroscopic interferences arise when the plasma contains ionic species with an m/z value the same as the analyte ion. Spectroscopic interference can be categorized as isobaric, polyatomic ions, and...
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Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

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Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and signal-to-noise ratio for the analyte. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.
Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called collision-induced...
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Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

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Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
654
Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

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In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then...
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High-Resolution Mass Spectrometry (HRMS)01:15

High-Resolution Mass Spectrometry (HRMS)

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The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the sum of the masses of protons and neutrons inside, considering the masses of protons and neutrons as equal. However, the masses of the proton (1.6726 × 10−24 g) and neutron (1.6749 × 10−24 g) are not truly equal. There is a minor error in the expression of atomic masses relative to the simplest atom of hydrogen. For...
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Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation01:26

Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation

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Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
There are three main types of inductively coupled plasma atomic emission spectroscopy  (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used....
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对于可互操作的多实验室综合组合分析的FT-ICR-MS仪器的协调.

Stefan A Pieczonka1,2, Mary J Thomas3, Philippe Schmitt-Kopplin1,2

  • 1Analytical Food Chemistry, TUM School of Life Sciences, Technical University of Munich, 85354 Freising, Germany.

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概括

为了数据的一致性,在不同里埃变换离子循环子子共振质谱仪 (FT-ICR MS) 仪器之间实现可比的分子概况至关重要. 这项研究表明,仔细的仪器调整使得高频谱重叠和可靠的数据,即使在不同的FT-ICRMS系统.

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科学领域:

  • 分析化学 分析化学
  • 质谱测量质量谱测量
  • 环境科学 环境科学

背景情况:

  • 里埃变换离子循环子共振质谱仪 (FT-ICR MS) 仪器的运行寿命长,但设计不断发展.
  • 构成光谱可比性的变化是一个关键问题,特别是在直接输液方法中.
  • 确保FT-ICR MS不同代和模型的数据一致性对于长期研究至关重要.

研究的目的:

  • 用不同的仪器模型证明FT-ICR MS分子谱的实验室间可比性.
  • 评估先进的细胞技术 (Infinity Cell和ParaCell) 对光谱数据质量的影响.
  • 在多种FT-ICRMS平台上验证复杂样品分子分析的可靠性.

主要方法:

  • 使用了一个12T solariX (无限电池) 和一个7T scimaX (ParaCell) FT-ICR MS.
  • 采用密切匹配的样品引入和离子导引系统.
  • 分析了具有分析挑战性的物食样本,并进行了无监督的多变量分析 (PCA).

主要成果:

  • 实现了类似的仪器性能指标 (解析能力,质量误差,特征数量,S/N比率,m/z分布).
  • 观察到高光谱重叠 (高达78%,高强度特征高达95%) 和类似的相对丰度.
  • 帕拉塞尔证明了空间电荷干扰的减少,避免了专门的校准方法.
  • PCA揭示了一致的样本配置文件,在各种仪器中没有系统偏差.

结论:

  • 仔细的仪器调整使不同FT-ICRMS系统之间的分子配置可比.
  • 高频谱重叠和一致的数据质量是可以实现的,支持使用广泛的数据库.
  • 这种可比性确保了FT-ICR MS长期和合作项目的数据的持续相关性.