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Updated: May 15, 2025

Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation
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Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson's Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation

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指挥官复合体调节 lysosomal 功能,并与帕金森病风险有关

Georgia Minakaki1, Nathaniel Safren1, Bernabe I Bustos1

  • 1Davee Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.

Science (New York, N.Y.)
|April 10, 2025
PubMed
概括

GBA1的遗传变异与帕金森病 (PD) 和患有莱维体的痴呆症 (DLB) 有关. 研究人员确定COMMD3是影响GCase活性和溶解体功能的关键蛋白质,这表明它是神经退行性疾病的新治疗点.

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