抗菌精油作为辅助剂,抑制多药耐药细菌的抗生素耐药性
Rafael Torres-Martínez1, Yolanda Magdalena García-Rodríguez1, María Guadalupe Ramírez-Ortiz1
1Laboratorio de Ecología Química y Agroecología, Instituto de Investigaciones en Ecosistemas y Sustentabilidad, Universidad Nacional Autónoma de México, Campus Morelia, Morelia, Mexico.
来自Lippia graveolens和Artemisia ludoviciana的精油可以对抗抗生素耐药性. 这些天然产品具有抗菌作用,可以增强抗生素对抗多药耐药细菌的疗效.
科学领域:
- 自然产品化学 自然产品化学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗生素耐药性的上升构成了全球健康的重大威胁.
- 越来越多的抗药性 (MDR) 细菌菌株,包括 Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis 和 Salmonella typhi,越来越普遍.
- 天然产品,如精油,提供潜在的替代策略来打击抗生素耐药性.
研究的目的:
- 研究来自Artemisia ludoviciana,Lippia graveolens和Cosmos bipinnatus的精油 (EO) 的抗菌和抗生素耐药性调节活动.
- 评估这些EO与常规抗生素相结合时对MDR细菌菌株的协同作用潜力.
主要方法:
- 采用双重活性勘探策略,选EO的抗菌和抗药性调节效应.
- 确定了EO及其与抗生素对抗特定MDR细菌菌株的组合的最小抑制度 (MIC).
- 通过测量在EO存在时抗生素MICs的减少来评估抗生素耐药性调节.
主要成果:
- 这三种EO (A. ludoviciana,L. graveolens,C. bipinnatus) 都对测试的MDR菌株表现出直接的抗菌活性,MIC从0.1735到65.6263μg/mL不等.
- 利皮亚严重的EO表现出显著的耐药性调节,特别是与万科米辛,纳利迪克酸和氨基醇对抗S. aureus,E. faecalis和P. aeruginosa.
- 阿尔特米西亚·卢多维奇亚纳 (Artemisia ludoviciana EO) 也表现出对黄金菌和菌的抗性调节,而Cosmos bipinnatus EO没有表现出显著的调节活性.
结论:
- 来自L. graveolens和A. ludoviciana的精油具有抗菌性质和抑制细菌对抗生素耐药性的能力.
- 这些EO代表了作为辅助疗法治疗由MDR病原体引起的感染的有希望的候选人.
- 这些天然产品的双重活性为解决抗生素耐药性危机提供了有价值的策略.
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