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丹麦超重/肥胖和胃肠道疾病发病率 - - 一项队列研究
Sigrid Bjerge Gribsholt1,2,3, Dóra Körmendiné Farkas1, Peter Jepsen1,4
1Department of Clinical Epidemiology, Center for Population Medicine, Aarhus University and Aarhus University Hospital, 8200 Aarhus N, Denmark.
超重和肥胖显著增加患各种胃肠道疾病的风险. 这种不断增长的肥胖流行病对胃肠道健康构成重大未来临床挑战.
科学领域:
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 肥胖是一种全球性流行病,与众多的健康并发症有关.
- 胃肠道 (GI) 疾病对全球医疗保健系统构成重大负担.
- 了解肥胖和特定的胃肠道疾病之间的联系对于预防策略至关重要.
研究的目的:
- 调查超重/肥胖与个体胃肠道疾病发病率之间的关联.
- 量化与普通人群相比,超重/肥胖个体的各种GI疾病的风险.
主要方法:
- 从1997年到2018年,丹麦进行了一项全国性的队列研究.
- 被诊断为超重/肥胖的个人是使用全国医疗保健登记册来识别的.
- 一个年龄和性别匹配的普通人口队列被用于比较.
主要成果:
- 超重/肥胖队列 (n=129,466) 的肠道疾病发病率较高 (30.1/1000人/年),与对照组 (16.7/1000人/年) 相比,调整后危险比率 (aHR) 为1.7.
- 在多种胃肠道疾病中观察到高风险,包括胆病 (aHR=2.8),胆囊炎 (aHR=2.6),急性胰腺炎 (aHR=2.2),胃 (aHR=2.0),肝硬化 (aHR=1.5),以及胃肠道癌 (aHR=1.2).
- 与男性 (aHR=1.4) 和老年人 (≥70岁,aHR=1.3) 相比,女性 (aHR=1.9) 和年轻成人 (18-29岁,aHR=2.6) 的风险更高.
结论:
- 超重/肥胖是广泛的胃肠道疾病的重要危险因素.
- 这些发现凸显了与肥胖相关的胃肠道疾病所带来的日益严重的临床挑战.
- 解决肥胖问题的公共卫生倡议对于减轻未来的胃肠道疾病负担至关重要.
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