在良性前列腺增生手术后的阿片类药物处方模式
Laura E Gressler1, Christina Sze2, Ananth Punyala3
1Division of Pharmaceutical Evaluation and Policy, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
概括
在手术室 (OR) 接受良性前列腺增生 (BPH) 手术的男性在手术后接受了更多的阿片类药物处方. 这表明潜在的过度处方,突出需要改进疼痛管理策略和非阿片类药物替代品.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 良性前列腺增生 (BPH) 是一种常见的疾病,需要手术干预.
- 在BPH手术后进行术后疼痛管理至关重要.
- 了解阿片类药物处方模式对于优化患者护理至关重要.
研究的目的:
- 分析和比较BPH手术后的阿片类药物处方行为.
- 调查手术室 (OR) 和非手术室 (非OR) 手术环境之间的术后阿片类药物使用的差异.
主要方法:
- 使用IQVIA PharMetrics® Plus数据库 (2015-2020) 进行的回顾性队列研究.
- 包括6022名为BPH进行手术的男性.
- 倾向性得分分析和逆概率治疗加权,调整了混因子.
主要成果:
- 在OR设置中接受BPH手术的患者与非OR设置 (28.00%) 相比,阿片类药物处方率更高 (42.78%).
- 调整后的模型显示OR手术中阿片类药物处方的几率明显更高 (OR 1.922).
- 没有观察到累积日数或吗啡等效每日剂量 (MEDD) 的显著差异,但处方时间分布不同.
结论:
- 在OR设置中的BPH手术与术后阿片类药物处方的可能性增加有关.
- 研究结果表明,可能存在过度处方和需要加强疼痛管理策略.
- 建议包括探索非阿片类药物替代品,并进一步研究实际阿片类药物消费和患者特定因素.
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