糖尿病患者和没有糖尿病患者之间乳腺癌全身治疗的差异
Chunhuan Lao1, Jason Gurney2, James Stanley2
1Te Huataki Waiora School of Health, The University of Waikato, Hamilton, Aotearoa New Zealand.
The New Zealand medical journal
|April 10, 2025
概括
糖尿病妇女接受的乳腺癌治疗较少,包括化疗,内分泌和HER2向疗法. 这种差异在太平洋地区妇女和II期乳腺癌患者中最为明显.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 糖尿病是影响癌症患者的流行并发症.
- 基于并发症的乳腺癌的系统治疗差异需要调查.
研究的目的:
- 为了确定糖尿病是否会影响接受乳腺癌全身疗法.
- 为了确定特定的治疗方式和受糖尿病影响的患者子组.
主要方法:
- 利用了来自Te Rēhita Mate Ūtaetae - 乳腺癌基金会国家登记 (2005-2020) 的数据.
- 使用后勤回归来比较糖尿病患者和非糖尿病患者之间的治疗率 (内分泌,HER2向,化疗).
- 根据诊断时的年龄和并发病情况进行调整.
主要成果:
- 糖尿病患者对所有全身疗法的概率较低:内分泌疗法 (60.4%对64.2%),HER2向疗法 (54.8%对65.6%) 和化疗 (20.4%对32.1%).
- 内分泌和HER2向疗法接收的差异在很大程度上是由年龄和并发症解释的.
- 经过调整后,化疗差异仍然存在 (OR 0.85),特别是在II期乳腺癌 (OR 0.71) 和太平洋妇女 (OR 0.70) 中.
结论:
- 患有糖尿病的女性不太可能接受乳腺癌化疗.
- 化疗的差异在太平洋地区妇女和II期疾病患者中最为显著.
- 糖尿病患者内分泌和HER2向治疗率较低的原因是年龄较大和并发症.
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