带有和没有听力损失的耳中的结构性大脑模式异常
Li Qin1, Qiu Ge2, Chaoqi Shi3
1Centre for Cognition and Brain Disorders/Department of Neurology, The Affiliated Hospital of Hangzhou Normal University, PR China; TMS center, Deqing Hospital of Hangzhou Normal University, Deqing, Zhejiang, PR China.
Hearing research
|April 10, 2025
概括
耳和听力损失导致大脑灰质体积的变化. 耳困扰与特定大脑区域的结构变化相关,而听力损失影响着单独的模式,这表明了不同的管理方法.
科学领域:
- 神经科学是一个神经科学.
- 听力学 听力学是指听力学.
- 放射学 放射学是一门学科.
背景情况:
- 主观耳经常与听力损失同时发生,共享潜在的病理生理机制.
- 这种并发症导致大脑中广泛的灰质体积 (GMV) 变化,影响神经网络.
- 多变量分析对于理解与耳和听力损失相关的独特结构性大脑变化至关重要.
研究的目的:
- 调查与耳和同时发生的听力损失相关的特定结构性大脑模式.
- 为了区分由单独的耳引起的神经网络改变与带有听力损失的耳.
- 探索这些结构性大脑模式和临床特征 (如耳困扰和抑郁症状) 之间的关系.
主要方法:
- 对50名耳患者和50名匹配对照进行了结构性MRI和听力测量.
- 患者被分为有听力损失的耳 (T+HL) 和没有听力损失的耳 (T-HL) 两组.
- 源式形态测量 (SBM),一种基于独立组件分析 (ICA) 的方法,分析了GMV模式. 斯皮尔曼的相关性检查了与临床数据的关联.
主要成果:
- 在没有听力损失 (T-HL) 的 tinnitus 患者中,中间前额叶皮质,前皮质和听力皮质的结构异常与 tinnitus 困扰有负相关性.
- 在有听力损失 (T+HL) 的耳患者中,涉及胰岛的结构性大脑模式与抑郁症状有负面关联.
结论:
- 耳相关的结构性大脑模式涉及中额头,补充运动区域 (SMA) 和前带状皮质 (ACC),与痛苦负相关,表明适应机制.
- 涉及胰岛,膜和上旋的结构性大脑模式主要受到听力损失的影响.
- 这些发现支持听力计分组在声管理中的临床实用性.
相关概念视频
01:31Hearing
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
01:14Brain Imaging
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).
01:21Perceiving Loudness, Pitch, and Location
The human brain perceives pitch through two primary mechanisms reflected in place theory and frequency theory. Each mechanism describes how sound waves are interpreted as specific pitches by the brain, offering insights into the intricate processes of auditory perception.
Place theory, or place coding, suggests that different pitches are heard because various sound waves activate specific locations along the cochlea's basilar membrane. The brain determines the pitch of a sound by identifying...
Place theory, or place coding, suggests that different pitches are heard because various sound waves activate specific locations along the cochlea's basilar membrane. The brain determines the pitch of a sound by identifying...