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Updated: May 15, 2025

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作为具有抗炎作用的高度选择性的BuChE抑制剂的卡瓦克罗尔/蒂摩尔衍生物:发现和生物评估

Yuan-Lin Zhang1, Hao-Yan Yang1, Jie Gou1

  • 1Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, Shanxi University of Chinese Medicine, Taiyuan, Shanxi 030619, China; College of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Taiyuan, Shanxi 030619, China.

Bioorganic chemistry
|April 10, 2025
PubMed
概括

新的卡瓦克罗尔/蒂摩尔衍生物被合成用于治疗阿尔茨海默病 (AD). 化合物SXF3可以选择性地抑制乙基胆酶 (BuChE) 和减少炎症,改善AD小鼠模型中的记忆.

关键词:
阿尔茨海默氏症的疾病是阿尔茨海默氏症.甲基胆化酶是一种甲基胆化酶.卡尔瓦克罗尔 (Carvacrol) 是一种炎症 炎症是一种炎症.蒂莫尔是指甲骨的部分.

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