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分子亚型的预后潜力,包括在子宫内膜卵巢癌中雌激素受体状态

Hein S Zelisse¹, Malou L H Snijders², Floris H Groenendijk³

¹Department of Pathology, Cancer Center Amsterdam, Amsterdam Reproduction & Development research institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.

Gynecologic oncology

|April 10, 2025

概括

雌激素受体 (ER) 状态改善了子宫内膜卵巢癌 (ENOC) 的预后预测,特别是在大型无特异分子谱 (NSMP) 亚组内. 负ERENOC瘤表明生存结果较差,指导个性化治疗策略.

科学领域:

妇科瘤学妇科瘤学
分子病理学分子病理学
癌症基因组学癌症基因组学

背景情况:

子宫内膜癌的积极分子风险分类器 (ProMisE) 将子宫内膜卵巢癌 (ENOC) 分为四个子组:POLEmut,MMRd,p53abn和NSMP.
在ENOC中,大型NSMP子组对临床适用性提出了挑战.
雌激素受体 (ER) 状态在NSMP子宫内膜癌中显示出预后价值.

研究的目的:

调查ER状态在ENOC分子子组中的预后价值.
确定ER状态是否可以在ENOC的NSMP子组内完善预测.

主要方法:

在手术治疗ENOC患者的多中心,回顾性队列研究 (1994-2021).
使用氨酸嵌入瘤组织进行分子分类.
通过免疫组织化学来确定ER状态.
使用日志等级测试和考克斯比例危险模型进行生存分析.

主要成果:

在纳入的167名ENOC患者中,NSMP小组占80.8%.
负ER瘤 (占所有瘤的12%) 与明显较低的10年整体存活率 (HR 3.51) 相关.
在NSMP小组中,ER阴性瘤 (11.1%) 的10年整体存活率较差 (HR 3.92).

结论:

在ENOC的NSMP子组内,ER状态显著改善了预后分层.
负ERENOC瘤与更差的预后有关.
这些发现支持基于分子和ER状态的ENOC个性化治疗策略的开发.

关键词:

"分类器"是指分类器.卵巢癌是子宫内膜质卵巢癌.雌激素受体的受体是什么预言预言预言预测因素是一个预测因素.

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