精神兴奋剂治疗如何改变ADHD成年人的大脑形态:sMRI与ADHD未服用药物的成年人进行比较研究
Sherief Ghozy1, Jennifer Meiza2, Ahmed Morsy3
1Department of Neuroradiology, Mayo Clinic, Rochester, MN, USA; Nuffield Department of Primary Care Health Sciences and Department for Continuing Education (EBHC program), Oxford University, UK.
Psychiatry research. Neuroimaging
|April 10, 2025
概括
对于成人多动症的兴奋剂治疗可能会改变大脑结构,特别是增加化和深度. 然而,在这项研究中,这些大脑变化并没有显著改善ADHD症状或灰质体积.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是已知的成人功能障碍的原因之一.
- 兴奋剂是首线ADHD治疗方法,但长期的疗效和耐受性是令人担忧的.
研究的目的:
- 研究兴奋剂治疗对ADHD成年人大脑形态学的长期影响.
- 为了将大脑的形态变化与冲动性得分相关联.
主要方法:
- 分析了26名患有多动症的成年人的结构性MRI数据.
- 治疗和未服用药物的个体之间的灰质体积,皮层厚度,状深度,化指数和碎形尺寸的比较.
- 使用巴拉特,迪克曼二世和艾森克的库存来评估冲动性.
主要成果:
- 治疗组表现出显著更高的基于表面的指标 (化指数,深度,碎形维度) (p < 0.05).
- 特定区域显示治疗成年人的化,深度和碎形尺寸增加.
- 冒险性得分与右前带带膜和右上尾回旋中的灰质体积相关.
结论:
- 刺激疗法对ADHD成年人的基于表面的大脑形态学产生了显著影响.
- 这些结构性大脑变化与临床ADHD得分或整体灰质体积的改善无关.
关键词:
更多关于 ADHD ADHD 的文章注意力缺陷多动障碍注意力缺陷多动障碍巴拉特的冲动性得分.迪克曼的冲动性库存-II.艾森克的冲动性库存灰色物质的体积,灰色物质的体积.这就是VBM的VBM.基于voxel的形态测量方法更多相关视频
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