用超短回声时间序列进行磁共振成像,用于头部和部放射治疗计划
Laura Sayaque1, Benjamin Leporq1, Charlène Bouyer2
1INSA-Lyon, Universite Claude Bernard Lyon 1, CNRS, Inserm, CREATIS UMR 5220, U1294, F-69100 Lyon, France.
概括
这项研究引入了用于放射治疗计划的超短回声时间 (UTE) MRI 序列. 这种方法从MRI数据中生成合成CT图像,为头癌治疗提供准确的剂量测量.
科学领域:
- 医疗成像医学成像
- 放射治疗 物理 物理
- 在瘤学瘤学.
背景情况:
- 放射治疗计划传统上使用CT扫描.
- 磁力共振成像为头部和部成像提供了卓越的软组织对比度.
- 从MRI直接绘制电子密度图是具有挑战性的.
研究的目的:
- 开发基于MRI的放射治疗计划,使用超短回声时间 (UTE) 序列.
- 为具有高度解剖变异性的区域生成合成CT (sCT) 图像.
- 为了治疗规划,将MRI信号强度与电子密度联系起来.
主要方法:
- 对25名头癌患者进行了1小时的MRI UTE测序.
- 合成CT图像被生成并与参考CT扫描 (MAE) 相比较.
- 用剂量差异和马分析对CT和sCT进行剂量比较.
主要成果:
- 在sCT和CT之间,平均绝对误差 (MAE) 为210.9 HU.
- 平均3D全球马通道率为93.1% (3%/3mm),89.2% (2%/2mm) 和80.9% (1%/1mm).
- 计划瘤体积 (PTV) 中位数剂量差异为70Gray的0.87%.
结论:
- UTE序列为放射治疗规划提供了直接的,基于物理的方法.
- 这种新的序列与临床工作流程和获取时间兼容.
- 使用sCT的剂量测量结果与复杂解剖区域的参考CT相似.
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