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动脉旋转标记基于MRI的输液模式与帕金森病中的运动功能障碍和L-DOPA反应性有关

Qianshi Zheng¹, Weijin Yuan¹, Jiaqi Wen¹

¹Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009 Hangzhou, China; Joint Laboratory of Clinical Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

NeuroImage. Clinical

|April 10, 2025

概括

这项研究使用动脉旋转标记 (ASL-PDRP) 确定了与帕金森病 (PD) 相关的模式. 这种模式可以预测PD患者的运动进展和降低的勒沃多巴 (L-DOPA) 反应.

科学领域:

神经成像是一种神经成像.
生物标志物生物标志物
神经退行性疾病神经退行性疾病

背景情况:

了解帕金森病 (PD) 的内在模式对于诊断和治疗监测至关重要.
动脉旋转标签 (ASL) 提供了一种非侵入性方法来评估脑 perfusion.
之前的研究已经探索了各种成像技术,以确定PD特定的模式.

研究的目的:

使用ASL技术 (ASL-PDRP) 确认与PD相关的协差模式 (PDRP).
评估ASL-PDRP在预测PD运动症状进展方面的潜力.
评估ASL-PDRP能够预测降低对利沃多巴 (L-DOPA) 治疗反应的能力.

主要方法:

使用原始 (179 PD, 62 NC) 和验证 (36 PD, 19 NC) 队列构建和验证ASL-PDRP.
使用等级线性回归,对ASL-PDRP表达与运动症状的相关性进行横截面和纵向分析 (UPDRS III).
卡普兰-梅尔分析预测54名L-DOPA治疗的PD患者的列沃多巴反应性降低.

主要成果:

在两个队列中,ASL-PDRP被成功识别,在PD患者中表达更高,与正常对照 (NC) 相比 (P = 0.017,AUC = 0.598;P = 0.024,AUC = 0.661).
ASL-PDRP表达与基线运动症状相关 (UPDRS III,轴性症状,刚性,勃拉迪基尼西亚).
在ASL-PDRP预测了未来的UPDRS III进展 (P = 0.021) 和较慢的levodopa反应性降低与轴性症状 (P = 0.031) 的患者.

结论:

ASL-PDRP是一种有前途的成像生物标志物,用于表征帕金森病.
这种模式显示了预测PD运动进展的潜力.
ASL-PDRP还可以预测随着时间的推移,乐伏多巴 (L-DOPA) 治疗反应的变化.

关键词:

动脉旋转标签的标签莱沃多巴的反应性莱沃多巴的反应性磁共振成像技术磁共振成像技术运动症状运动症状神经成像是一种神经成像.帕金森病是帕金森氏症的一种疾病.一个模式的模式模式.

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