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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Complement System01:27

Complement System

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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
1.9K
Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
411
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Overview
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相关实验视频

Updated: May 15, 2025

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
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Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

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补充系统与瘤微环境中的其他免疫通路之间的相互作用.

Cecilia Garlanda1, Monica Dambra2, Elena Magrini2

  • 1Department of Biomedical Sciences, Humanitas University, Milan, Pieve Emanuele 20072, Italy; IRCCS, Humanitas Research Hospital, Milan, Rozzano 20089, Italy.

Seminars in immunology
|April 10, 2025
PubMed
概括

补充系统是补充系统.

科学领域:

  • 免疫学和癌症生物学:研究补充系统在瘤进展和免疫逃避中的双重作用.

背景情况:

  • 瘤微环境 (TME) 极大地影响癌症的生长和扩散.
  • 炎症通路,包括补体系统,在塑造TME和抗瘤免疫力方面发挥着重要作用.

研究的目的:

  • 阐明补充激活在癌症中的复杂且往往矛盾的作用.
  • 探索补充体,免疫细胞 (特别是髓状细胞) 和瘤进展之间的相互作用.
  • 评估向癌症治疗中的补充通路的治疗潜力,特别是巨细胞重编程.

主要方法:

  • 对癌症相关炎症和免疫抑制中补充激活的临床前研究的综述.
  • 分析瘤微环境中的补充成分和免疫细胞之间的相互作用.
  • 检查与补充向治疗相关的临床试验数据和结果.

主要成果:

  • 补充激活可以促进瘤生长和免疫抑制,特别是通过髓状细胞的参与.
  • 补体的具体作用高度依赖于环境,因瘤类型,阶段和其他微环境因素而有所不同.
  • 临床前数据表明,补充向可以增强免疫疗法,但临床试验失败凸显了复杂性.

结论:

  • 补充系统在瘤学中是一个复杂的治疗目标,因为它具有多方面的作用.
关键词:
与癌症有关的炎症.补充 补充 补充 补充巨细胞是一个巨细胞.骨髓状细胞是骨髓状细胞.与瘤有关的瘤.与瘤相关的中性粒细胞

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  • 需要进一步的研究来确定哪些患者可以从特定的补充向疗法中受益.
  • 向补充剂,特别是与巨细胞重编程相结合,有望提高癌症治疗疗效.