超越MERS:美尔贝病毒受体的可塑性要求应急准备
Jarel Elgin Tolentino1, Spyros Lytras2, Jumpei Ito3
1Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan.
Cell host & microbe
|April 10, 2025
概括
梅尔贝科病毒表现出适应性ACE2结合,其中一个基因系使用人类ACE2. 这种受体可塑性强调了对新出现的病毒威胁保持警的需要.
科学领域:
- 病毒学 病毒学
- 分子生物学分子生物学
- 传染性疾病 传染性疾病
背景情况:
- 默贝科病毒是一种已知感染各种宿主的病毒属.
- ангиотензин转化酶2 (ACE2) 是几个冠状病毒的关键受体,包括SARS-CoV-2.
- 了解病毒受体相互作用对于预测宿主热带性和动物感染潜力至关重要.
研究的目的:
- 为了研究美尔贝科病毒独特的ACE2结合相互作用.
- 确定具有新型ACE2结合能力的merbecovirus血统,包括人类ACE2.
- 为了评估merbecoviruses的受体可塑性.
主要方法:
- 对不同merbecovirus菌株中ACE2结合亲缘关系的比较分析.
- 识别和描述新型梅尔贝科病毒系.
- 病毒-ACE2相互作用的in silico和in vitro研究.
主要成果:
- 在不同的merbecoviruses中观察到不同的ACE2结合模式.
- HKU5血统证明了从众多非人类宿主中利用ACE2的能力.
- 确定了一种具有结合人类ACE2的能力的新型HKU5系.
结论:
- 默贝科病毒表现出显著的受体可塑性,特别是在它们与ACE2的相互作用中.
- 人类ACE2利用的merbecovirus血统的出现是一个潜在的公共卫生问题.
- 这些发现强调了持续监测和为潜在的merbecovirus溢出事件做好准备的重要性.
相关概念视频
Diversity of Antigen Receptors
393
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
393
Viral Recombination
23.1K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.1K
Receptor Downregulation in MVBs
2.0K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.0K
Cross-reactivity
30.9K
Overview
30.9K
Leaky Scanning
5.0K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.0K
Surface Membrane Barriers
693
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
693


