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相关概念视频

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.0K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

2.4K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.4K
The Thyroid Gland01:23

The Thyroid Gland

3.4K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
3.4K

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相关实验视频

Updated: May 15, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

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在甲状腺功能测试中的宏TSH干扰:一个案例报告和文献综述

Hong-Gang Sun, Li-Qin He

    Clinical laboratory
    |April 10, 2025
    PubMed
    概括

    宏观TSH可以导致甲状腺刺激激素 (TSH) 水平错误升高,导致误诊. 在这种情况下,PEG6000治疗证实了宏TSH,防止了不必要的甲状腺治疗.

    科学领域:

    • 内分泌学 在内分泌学.
    • 临床化学 临床化学
    • 免疫学 免疫学 免疫学

    背景情况:

    • 甲状腺刺激激素 (TSH) 通过负反调节甲状腺激素的产生.
    • TSH测试对于诊断和管理甲状腺疾病至关重要.
    • 诸如异种性抗体,甲状腺激素自身抗体 (THAb) 和宏TSH等因素可以干扰TSH测试的准确性.

    研究的目的:

    • 调查干扰因素对TSH测试的影响.
    • 强调在甲状腺功能测试中识别和排除宏TSH的重要性.
    • 展示一个宏观TSH导致不准确的TSH结果的案例.

    主要方法:

    • 使用化学发光免疫测试 (CLIA) 进行甲状腺功能测试.
    • 在没有甲状腺疾病史的患者中评估了TSH,FT3和FT4水平.
    • 使用聚乙烯糖6000 (PEG6000) 沉物来识别宏观TSH干扰.

    主要成果:

    • 与参考范围相比,最初的TSH水平显著升高 (16.1751μIU/mL).
    • 自由T3,自由T4,总T3和总T4水平在正常范围内.
    • 在PEG6000治疗后,TSH水平正常化至0.98μIU/mL,证实了宏观TSH.

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    结论:

    • 宏观TSH可以导致错误的TSH升高,可能导致误诊和不适当的治疗.
    • PEG6000沉是一种有效的检测宏观TSH的方法.
    • 临床相关性和干扰因素的排除对于准确的甲状腺功能评估至关重要.