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定义外围状克罗恩病的放射治疗:一个TOpClass全球专家德尔菲共识共识
Easan Anand1, Jalpa Devi2, David H Ballard2
1Imperial College London, London, United Kingdom; St Mark's The National Bowel Hospital, Harrow, United Kingdom.
概括
这项研究建立了一个国际共识,用于定义使用MRI的近结核性克罗恩病 (pfCD) 的放射治疗方法. 新定义提高了临床试验和pfCD患者护理的一致性.
科学领域:
- 胃肠病学 胃肠病学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 周围结核性克罗恩病 (pfCD) 影响患者的生活质量,影响了克罗恩病 (CD) 患者的五分之一.
- 磁共振成像 (MRI) 是评估pfCD.fistula愈合的标准.
- 目前对MRI评估的放射学定义缺乏一致性,阻碍了临床解释和试验设计.
研究的目的:
- 建立一个国际共识,关于辐射治疗的定义在周围囊性克罗恩病 (pfCD).
主要方法:
- 这是一项两阶段的研究,包括对pfCD治疗的MRI变量进行系统审查,以及与84名国际专家进行的两轮在线Delphi共识过程.
- 使用基于共识的健康测量仪器选择标准 (COSMIN) 框架来评估方法质量.
- 通过利益相关者会议达成共识,根据准确共识报告文件 (ACCORD) 准则报告结果.
主要成果:
- 放射治疗的定义是没有T2加权的超强度,完全纤维化的管,并且在对比后的T1加权图像上没有对比增强 (95%的共识).
- 放射性改善是由日益纤维化的通道或T2超强度,直径,长度,瘤大小或对比度增强 (80%的共识) 的减少来定义的.
结论:
- 这一国际共识标准化了pfCD的放射性终点,提高了临床实践和研究的一致性.
- 未来的研究将验证这一定义及其与长期临床结果和生活质量的相关性.
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