对胃胃肠道 stromal 瘤生存结果的性别差异进行了基于人口的分析
Xia Ren1, Ganhong Wang2, Jian Chen1
1Department of Gastroenterology, Changshu Hospital Affiliated to Soochow University, Suzhou, China.
概括
男性胃肠道 stromal 瘤 (gGIST) 患者的整体存活率 (OS) 和癌症特异性存活率 (CSS) 比女性更差. 手术干预可以改善两性GGIST预后.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 流行病学 流行病学
背景情况:
- 性别差异影响瘤预后,但它们对胃肠道瘤 (gGISTs) 存活率的影响尚不清楚.
- 监测,流行病学和最终结果 (SEER) 数据库用于调查gGIST预后中人口层面的性别差异.
研究的目的:
- 调查胃胃肠道 stromal 瘤 (gGISTs) 的预后中的性别差异.
- 分析临床特征对gGIST患者的整体生存期 (OS) 和癌症特异性生存期 (CSS) 的影响.
主要方法:
- 利用SEER数据库获取2000-2019年gGIST患者的数据.
- 员工倾向分数匹配 (PSM) 以尽量减少选择偏差.
- 进行卡普兰-梅尔分析和考克斯比例危险模型来评估生存结果.
主要成果:
- 分析了3006名gGIST患者 (1459名男性,1547名女性);男性患有更先进的T阶段,更大的瘤和更高的线粒体指数.
- 男性患者在PSM前后 (P <.05) 显示的OS和CSS明显比女性更差.
- 多变量分析确定了年龄,种族,性别,M阶段,手术,瘤大小和线粒体指数作为OS和CSS的独立风险因素.
结论:
- 男性和女性gGIST患者之间存在不同的临床特征.
- 患有gGIST的女性患者往往有改善的整体生存率和癌症特异性生存率.
- 手术治疗是改善gGIST患者预后的一个潜在因素.
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