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在脑血管疾病中成像间歇性液体和细胞外矩阵:当前的观点和临床应用

Grant McGee Talkington¹, Blake Ouvrier¹, Amanda Louise White²

¹Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA; Tulane Brain Institute, Tulane University, New Orleans, LA 70112, USA.

Neuroimaging clinics of North America

|April 10, 2025

概括

神经成像技术的进步揭示了细胞外基质 (ECM) 和细胞间流体 (ISF) 动态的变化如何与脑血管疾病有关,有助于早期检测和治疗.

科学领域:

神经成像是一种神经成像.
脑血管生物学脑血管生物学
生物医学工程生物医学工程

背景情况:

脑血管疾病涉及到大脑细胞外基质 (ECM) 和间歇液体 (ISF) 动态的复杂变化.
目前对这些ECM和ISF变化的理解在各种病理中仍然不完整.
需要新的成像技术来可视化和量化这些 in vivo 的变化.

研究的目的:

为评估脑血管疾病中ECM和ISF动态提供当前神经成像技术的全面审查.
探索ECM组成,ISF运动和特定的脑血管病理之间的相关性.
突出新型成像标记物及其在疾病管理中的临床应用.

主要方法:

对应于脑血管疾病的神经成像技术现有文献的综述.
对研究的分析,重点是细胞外矩阵 (ECM) 组件和间位液体 (ISF) 动态.
对ECM/ISF变化的新型成像标记物的识别和评估.

主要成果:

在ECM组成和ISF运动模式的变化与缺血性中风,前性痴呆症,脑小血管疾病,阿尔茨海默病和血管痴呆症有关.
针对ECM/ISF变化的新型成像标记物在区分这些病理方面显示出有前途.
神经成像为脑血管疾病的进展和机制提供了宝贵的见解.

结论:

神经成像技术对于可视化和量化脑血管疾病中ECM和ISF动态至关重要.
这些技术为早期发现疾病,监测疾病进展和指导治疗干预提供了潜力.
进一步开发用于ECM/ISF变化的成像标记物将加强脑血管疾病的临床管理.

关键词:

脑血管疾病脑血管疾病疾病生物标志物疾病生物标志物细胞外矩阵是细胞外矩阵.细胞外矩阵组件的组成部分.流体动力学流体动力学间歇性流体间歇性流体神经成像是一种神经成像.

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