血IL4水平与肺高血压的严重程度和结果有关
Yun Li1,2, Yi Liu1, Zhanping Liang1
1Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Clinical and experimental pharmacology & physiology
|April 10, 2025
概括
血中白血素-4 (IL4) 的较低水平表明肺高血压 (PH) 患者的风险更高,结果更差. 这一发现突出了IL4作为PH疾病严重程度和生存的潜在预后生物标志物.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 肺部病理学 肺部病理学
背景情况:
- 介质素-4 (IL4) 是一种抗炎性细胞因子,因其在心血管疾病中的保护作用而闻名.
- 在肺高血压 (PH) 中IL4的预后意义尚未明确确.
研究的目的:
- 在PH患者中量化血IL4水平.
- 调查IL4水平,PH风险和患者结果之间的关联.
主要方法:
- 一项观察性研究涉及766名PH患者和191名健康对照.
- 使用斯皮尔曼相关性,ROC曲线,考克斯回归和卡普兰-梅尔生存分析分析血IL4水平的分析.
- 使用决策曲线分析开发和验证用于死亡率预测的名录.
主要成果:
- 与对照组相比,PH患者的血IL4水平显著降低,并且在不同PH严重程度组中显著降低.
- 较低的IL4水平与增加的PH风险,疾病严重程度标志物 (NT-proBNP,mPAP) 和较差的生存率相关.
- IL4被确定为生存的独立预测因子,结合IL4,6MWD和NT-proBNP的诊断模型显示出良好的预后价值.
结论:
- 血IL4水平降低与PH患者的疾病严重程度增加有关.
- 较低的IL4水平是肺高血压患者不良结果的重要预后指标.
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