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Updated: May 15, 2025

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从小岛巨细胞中FFAR4介导的IL-6释放促进胰岛素分泌,并且在2型糖尿病中受到影响

Xinyi Chen1, Jingchen Shao1, Isabell Brandenburger1

  • 1Max Planck Institute for Heart and Lung Research, Department of Pharmacology, Bad Nauheim, Germany.

Nature communications
|April 10, 2025
PubMed
概括

岛屿巨细胞激活FFAR4释放IL-6,促进葡萄糖刺激胰岛素分泌 (GSIS). 这一途径在肥胖和2型糖尿病中受损,这表明FFAR4的重新激活是治疗点.

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