在对左结肠癌患者安装支架后,肠道阻塞的安全性和有效性分析
Xin Yan1, Teng Long2,3, Yi Xiao1
1Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Journal of cancer research and clinical oncology
|April 10, 2025
概括
肠道支架在阻塞的左结肠癌中提供了更好的短期结果,对长期存活没有影响. 与紧急手术相比,这种方法可以及时缓解肠道阻塞.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 在瘤学瘤学.
背景情况:
- 由肠道阻塞复杂的左结肠癌 (LCCO) 提出了重大管理挑战.
- 对于LCCO的紧急手术具有相当大的风险和发病率.
研究的目的:
- 评估肠道支架安置的安全性和有效性,作为LCCO患者手术的桥梁.
- 为了比较支架与急诊手术的短期和长期结果.
主要方法:
- 对111名LCCO患者的回顾性队列分析 (2015年1月 - 2019年8月).
- 支架组 (SG,n=41) 和急诊手术组 (EG,n=70) 的比较.
- 主要终点:3年无进展生存期 (PFS),局部复发,远程转移. 二级终点:整体3年生存率 (OS),手术内参数,肠静脉切割率,术后并发症,住院时间.
主要成果:
- 在SG和EG之间,在3年的PFS (59%与41%) 或OS (61%与44%) 之间没有显著的差异.
- 术后输血显著减少了手术内流血 (P=0.02),医院住院时间缩短 (P<0.001),术后并发症率降低 (P=0.012).
- 在研究队列中,支架完全避免了对肠静脉瘤的需要 (0%对100%,P<0.001).
结论:
- 肠道支架有效缓解LCCO患者的阻塞症状.
- 与紧急开放手术相比,支架提供了优越的短期结果.
- 支架不影响左结肠癌患者的长期瘤结果.
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