血管新生:生物机制和体外模型
Laura A E Brunmaier1, Tugba Ozdemir1, Travis W Walker2
1Nanoscience and Biomedical Engineering Department, South Dakota School of Mines & Technology, 501 E St. Joseph St., Rapid City, SD, 57701, USA.
Annals of biomedical engineering
|April 10, 2025
概括
使用人类细胞开发更好的体外血管模型可以改善药物和设备的翻译. 这些仿生模型提高了人类临床试验临床前测试的可靠性.
科学领域:
- 生物医学工程 生物医学工程
- 血管生物学 血管生物学
- 翻译科学 翻译科学
背景情况:
- 生物医学设备和药物翻译是昂贵和低效的,临床试验失败率很高.
- 动物模型对人类反应的预测价值有限,导致翻译失败.
- 血管系统在生物医学研究中至关重要,因此血管模型对于改善翻译至关重要.
研究的目的:
- 审查当前的体外血管和血管生成模型,以改善生物医学研究翻译.
- 确定创建仿生体外模型模拟体外环境的关键参数.
- 为设计可靠药物和设备查的人体体实验室模型提出前进道路.
主要方法:
- 在体外使用的常见血管性细胞因子和抑制剂的审查.
- 评估现有的体外模型是否能够捕捉物理环境.
- 在体外实现血管生物模拟的参数分析.
主要成果:
- 血管生成因子 (细胞因子和抑制剂) 对于启动和维持血管平衡在体外至关重要.
- 当前的体外模型在复制血管物理微环境的能力方面有所不同.
- 仿生学的关键参数包括理解细胞相互作用和细胞外矩阵.
结论:
- 工程人类体外血管模型模拟体内条件对于成功的生物医学翻译至关重要.
- 这些先进的模型可以作为更准确的药物和设备查平台.
- 预计改进的体外模型将增加FDA批准和临床试验的成功率.
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