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表观遗传衰老与COVID-19的关联:19年的纵向研究

Gabor Farkas¹, Zahira El Mahdaouy², Gergely Babszky¹

¹Research Institute of Sport Science, Hungarian University of Sport Science, Budapest, Hungary.

|April 10, 2025

概括

根据对54名志愿者的研究,COVID-19感染可能会加速表观遗传衰老. 研究人员观察到感染后衰老标志物增加,这表明对生物衰老过程的潜在轻微,长期影响.

科学领域:

表观遗传学和衰老研究.
传染病对生物衰老的影响.

背景情况:

已知衰老和COVID-19会影响DNA甲基化.
DNA甲基化变化可能会影响衰老速度和疾病风险.

研究的目的:

评估COVID-19对表观遗传衰老的影响.
在三年内评估生理功能和DNA甲基化变化.

主要方法:

在54名志愿者中评估了生理功能 (VO2max,握力,垂直跳跃) 在三年之前和之后.
利用八个表观遗传钟来测量衰老的速度.
分析了基因促进子区域 (H1FNT,CSTL1) 中的DNA甲基化变化.
对比了感染COVID-19的志愿者和没有感染的志愿者之间的衰老轨迹.

主要成果:

DNAmAge表示加速衰老;五个时钟显示衰老减缓.
在SkinBloodClock和DNAmTL.中,女性显示出更强的DNAmAge加速和减缓衰老.
在患有COVID-19的参与者中观察到衰老进展的显著增加 (DNAmGrimAge,DNAmGrimAge2,DNAmFitAge).
甲基化在H1FNT基因促进体下降,在CSTL1促进体增加.

结论:

COVID-19感染与加速表观遗传衰老有关.
这些发现表明COVID-19对表观遗传衰老的潜在温和,长期影响.
需要进一步的研究来了解机制和长期健康影响.

关键词:

在COVID- 19中,基因表观衰老基因表观衰老基因表观衰老基因表观表观表观时间表.H1 FNT FNT 的时间纵向的衰老纵向的衰老纵向的衰老

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