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Updated: May 23, 2025

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
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Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair

Published on: May 24, 2017

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在核酸切割修复中,对UvrA损伤检测和病变转移到UvrB的机制性理解

Marianna Genta1, Giulia Ferrara1, Riccardo Capelli2

  • 1Department of Pharmaceutical Sciences, University of Piemonte Orientale, Via Bovio 6, 28100, Novara, Italy.

Nature communications
|April 10, 2025
PubMed
概括

DNA 修复对染色体稳定性至关重要. 这项研究揭示了Mycobacterium tuberculosis中的UvrA-UvrB复合体如何通过协调受损DNA结合并形成关键中间复合体来启动核酸切除修复 (NER).

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Nucleotide Excision Repair

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
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