在轻度认知障碍中,与内在大脑功能障碍相关的自我相关的思维改变与内在大脑功能障碍有关
Povilas Tarailis1, Kim Lory1, Paul G Unschuld2,3
1Functional Brain Mapping Laboratory, Department of Fundamental Neuroscience, University of Geneva, Geneva, Switzerland.
Scientific reports
|April 10, 2025
概括
轻度认知障碍 (MCI) 通过损害思维漫游和改变大脑活动来破坏自我意识. 患有MCI的患者表现出与自我相关的想法减少,以及与记忆和自我感知相关的神经模式异常.
科学领域:
- 认知神经科学 认知神经科学
- 神经心理学 神经心理学
- 脑部成像 脑部成像
背景情况:
- 自我意识依赖于在思维漫游期间的内省思维.
- 了解轻度认知障碍 (MCI) 如何影响自我参考思维至关重要.
- 以前的研究并没有完全阐明MCI中的这些变化.
研究的目的:
- 调查MCI患者自我参考思维和思维漂泊的变化.
- 将MCI患者的认知和神经模式与健康的年轻人和老年人进行比较.
- 确定MCI中自我意识受损的神经相关物.
主要方法:
- 招募了30名MCI患者,60名健康的老年人和60名健康的年轻人.
- 使用蒙特利尔认知评估 (MoCA) 评估认知功能.
- 用阿姆斯特丹休息状态问卷 (ARSQ) 测量了心灵流浪,用高密度电脑图 (hdEEG) 微态分析测量了神经活动.
主要成果:
- 患有MCI的患者显示MoCA得分较低,特别是在记忆领域.
- 患有MCI的患者报告说,关于过去和未来经历的自我相关思想较少.
- 与对照者相比,hdEEG显示MCI患者的微状态C活动减少 (与自我相关的想法) 和微状态A活动增加,局限于记忆和默认模式网络区域.
结论:
- 脑游荡能力受损与MCI中的内在神经网络功能障碍有关.
- 特定微观状态中的异常神经活动与MCI中的自我参考思维缺陷相关.
- 这些发现表明,在MCI人口中,自我感受到破坏.
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