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Updated: May 15, 2025

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
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Published on: September 18, 2014

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ZNF593通过减弱cGAS-DNA结合来调节cGAS介导的先天免疫反应

Xuemei Bai1,2, Na Dong1,2, Nan Cao1,2

  • 1Key Laboratory of Infection, Immunity and prevention of Shandong Province & Key Laboratory for Experimental Teratology of Ministry of Education, Shandong University, Jinan, Shandong, PR China.

Cell death and differentiation
|April 10, 2025
PubMed
概括

指蛋白ZNF593通过抑制循环GMP-AMP合成酶 (cGAS) 激活,作为抗病毒免疫的负调节剂. 缺少ZNF593可增强对病毒感染的先天性免疫反应,并防止狼等自身免疫性疾病.

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