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Updated: May 15, 2025

Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding

Published on: June 9, 2017

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阶段性质子传感介导的GPCR激活的结构基础

Xiaolei Yue1,2, Li Peng1,2, Shenhui Liu1,2

  • 1iHuman Institute, ShanghaiTech University, Shanghai, China.

Cell research
|April 10, 2025
PubMed
概括

这项研究揭示了像GPR4和GPR65这样的pH感应G蛋白结合受体 (GPCR) 的结构机制,详细说明了它们如何检测酸度和激活. 这些发现为与pH相关的疾病提供了新的治疗点.

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Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET10:59

Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET

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