休息状态的fMRI揭示了与前体偏头痛患者平衡障碍相关的脑功能改变

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Xia Zhe¹, Miao Cheng¹, Hailian Zhang²

¹Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, 710068, Shaanxi, People's Republic of China.

Scientific reports

|April 10, 2025

概括

静脉偏头痛 (VM) 与严重的平衡问题有关,高头障碍库存 (DHI) 评分表明. 大脑成像显示了VM患者的功能变化,与他们的平衡困难相关.

科学领域:

神经科学是一个神经科学.
神经学神经学
医疗成像医学成像

背景情况:

静脉偏头痛 (VM) 经常导致严重的平衡障碍,由高的头障碍清单 (DHI) 评分表明.
了解这些平衡障碍的神经支对于有效治疗至关重要.

研究的目的:

为了评估VM患者的DHI得分异常.
在VM中探索大脑功能改变和平衡障碍之间的关系.
确定与VM中平衡缺陷相关的特定大脑区域和网络.

主要方法:

休息状态功能磁共振成像 (rs-fMRI) 用于54名VM患者和49名健康对照 (HC).
进行了区域同质性 (ReHo) 和基于种子的功能连接性 (FC) 分析.
皮尔森的相关性评估了大脑指标和DHI得分之间的关联.

主要成果:

与HC相比,VM患者的DHI得分明显高于VM患者.
在VM患者的前额轨道环 (FOG) 中观察到降低的ReHo,在中间环状皮质 (MCC) 中增加的ReHo.
在MCC ReHo和DHI得分之间发现了负相关性;在VM中注意到MCC和 precuneus (PreCu) 之间的改变FC.

结论:

大脑功能的改变,特别是FOG和MCC的改变,与VM的平衡障碍有关.
MCC和PreCu之间的异常功能连接进一步表明VM相关平衡问题的神经基础.
研究结果支持大脑功能变化在VM引起的平衡问题中的作用,并为物理治疗策略提供信息.

关键词:

平衡障碍影响平衡功能连接性的功能连接性.休息状态的fMRI.自发的大脑活动自发大脑活动.静脉导管偏头痛是一种偏头痛.

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