在胸腔镜手术期间,在全身麻醉下,西普罗对血液动力学的影响:一个随机,双盲,受控试验
Lifang Lan1, Jianping Liao1, Liuying Qin1
1Department of Anesthesiology, Cardiovascular Institute, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
BMC anesthesiology
|April 11, 2025
概括
在胸腔镜手术期间,西普罗为麻醉提供了比普罗波更安全的替代品,表现出可比的心血管稳定性,减少了注射疼痛和更快的恢复.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 心血管医学 心血管医学
背景情况:
- 普罗波福尔是一种常见的麻醉剂,可以导致血液动力学不稳定.
- 齐普罗是一种具有环基组的普罗波类型,具有潜在的安全性和疗效优势.
研究的目的:
- 为了评估西普罗与普罗波相比的血动力学效应,安全性和疗效.
- 评估Ciprofol作为胸腔镜手术麻醉剂的适用性.
主要方法:
- 一项前性,随机,双盲,受控的临床试验,涉及60名接受胸腔镜手术的患者.
- 患者接受了用西普罗或普罗波 (1:1比率) 的麻醉.
- 主要结局包括心血管事件和血液动力学参数波动;次要结局评估了注射疼痛和恢复时间.
主要成果:
- 两组之间心血管事件 (高血压,低血压,胆心梗塞,短心) 没有显著差异.
- 西普罗显示了平均动脉压的轻微下降 (p=0.02) 和较低的心率变化 (p=0.01).
- 西普罗导致注射疼痛减少 (10.0%与23.3%,p=0.028) 和毛反射的更快的损失 (p=0.004).
结论:
- 西普罗是一种安全有效的麻醉剂,用于胸腔镜手术.
- 它可以被认为是可行的替代品的propofol,提供更好的安全性和有效性.
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