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Updated: May 15, 2025

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通过与GPCR相关的分类器选的SIGMAR1调节了膀癌中的细胞内膜网膜应激
Jingming Zhuang1, Yang Wang1, Xinyong Wu2
1Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Journal of translational medicine
|April 11, 2025
概括
这项研究确定了基于G蛋白合受体 (GPCRs) 和瘤微环境 (TME) 的膀癌预后的新分类器. 西格玛-1受体 (SIGMAR1) 是促进膀癌生长的关键因素,与生存率低下有关.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 膀癌 (BC) 是全球流行的一种恶性瘤.
- G蛋白结合受体 (GPCRs) 影响癌症信号传递和瘤微环境 (TME).
- 西格玛-1受体 (SIGMAR1) 在BC中的作用及其对ER压力的调节仍然不清楚.
研究的目的:
- 使用GPCR和TME特征开发膀癌的预后分类器.
- 研究SIGMAR1在膀癌进展中的特定作用和机制.
- 探索SIGMAR1,ER压力和BC免疫细胞透之间的关系.
主要方法:
- 利用公共数据集进行测序,免疫治疗反应和临床数据.
- 开发并验证了使用多omics和生物信息学方法的GPCR-TME分类器.
- 通过体外和体内实验研究SIGMAR1的功能,包括西方抹黑和异种移植模型.
主要成果:
- 建立了一个GPCR-TME分类器,与BC患者的整体存活期 (OS) 有显著的相关性.
- 在BC组织中SIGMAR1表达升高,并与预后不佳有关.
- 缺少SIGMAR1减少了癌细胞的入侵,增殖和异种移植的生长,同时增强了ER压力和亡.
结论:
- GPCR-TME分类器有效预测BC患者的预后,并将SIGMAR1确定为ER压力的关键调节者.
- 向SIGMAR1可能通过破坏其对ER压力的保护作用和促进BC细胞亡来提供一种新的治疗策略.
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